尿道下裂的细菌学研究

目的 探索尿道下裂术后的再造尿道易于感染的原因、感染源及细菌种类；据此改进围手术期处理措施，以降低感染率。方法 应用细菌培养鉴定、基因分型鉴定等从分子水平证实细菌的来源及种类。结果 经尿道外口逆行进入和再造尿道材料携带是细菌主要来源。引起尿道下裂感染主要是革兰氏阳性球菌。最有效抗生素是去甲万古霉素。结论 尿道下裂术后感染是切口感染而不是泌尿系感染。再造尿道感染率高于皮肤(黏膜)的原因在于造成了比体表更适合细菌生长繁殖的微环境。

Bacteriology study of hypospadias

Objective This clinical study was to explore why the neo urethra is liable to be infected after hypospadias operation, find the source and the common floras of infection, and accordingly, improve the perioperation procedures so as to reduce postoperative infection rate. Methods The pathogenic floras were examined and analyzed by germiculture and karyotype analysis. Results The bacteria in the neo urethra mostly came from the orifice and the reconstruction material of the urethra. The most common floras that caused infection were gram positive coccus. The most sensitive antibiotics for hypospadias infection were demethylvancomycin. Conclusions The postoperative infection of hypospadias is incisional, not the urinary system infection. Because the microenvironment of the neo urethra is more suitable for infection than that of the skin or mucosa, the reconstructed urethra is likely to be infected. ;