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吉西他滨联合大剂量顺铂治疗晚期非小细胞肺癌
引用本文:黄举鹏,刘冬生,郑敏相,林漳国. 吉西他滨联合大剂量顺铂治疗晚期非小细胞肺癌[J]. 现代肿瘤医学, 2005, 13(2): 253-254
作者姓名:黄举鹏  刘冬生  郑敏相  林漳国
作者单位:广东东莞太平人民医院肿瘤科,广东,东莞,523900
摘    要:目的观察吉西他滨(Gemcitabine GEM)联合大剂量顺铂(HD—DDP)方案治疗晚期非小细胞肺癌(ANSCLC)的近期疗效及其不良反应。方法经病理组织学或细胞学证实的26例晚期非小细胞肺癌用吉西他滨1000mg/m^2。静脉滴注,第1,8,15天,顺铂80~100mg/m^2静脉滴注,第1天,4周为1周期。所有病人至少接受2周期治疗。结果可评价疗效26例,总有效率46.2%,初治病例14例,有效率57.1%。复治病例12例,有效率33.3%。主要毒副作用是骨髓抑制,恶心呕吐,其他毒性反应均轻微可耐受。结论吉西他滨联合大剂量顺铂治疗晚期非小细胞肺癌具有较好疗效,毒性可耐受,是治疗晚期非小细胞肺癌较理想方案之

关 键 词:吉西他滨 大剂量顺铂 晚期非小细胞肺癌 联合化疗
文章编号:1672-4992(2005)02-253-02
修稿时间:2004-12-29

Clinical observation of combined chemotherapy of gemcitabine and HD - DDP for advanced non - small - cell Lung cancer
HUANG Ju-peng,LIU Dong-sheng,ZHENG Min-xiang,et al.. Clinical observation of combined chemotherapy of gemcitabine and HD - DDP for advanced non - small - cell Lung cancer[J]. Journal of Modern Oncology, 2005, 13(2): 253-254
Authors:HUANG Ju-peng  LIU Dong-sheng  ZHENG Min-xiang  et al.
Affiliation:HUANG Ju-peng,LIU Dong-sheng,ZHENG Min-xiang,et al.Department of Oncology,The People's Hospital o f Tai Ping,Dong guan,Guang dong 523900,China.
Abstract:Objective To evaluate the efficacy and to xi city of Gemcitabine and HD-DDP for advanced non-small-cell lung cancer. Methods Twenty six patients with ANSCLC diagnosed by pathology or cytology were enrolled in the study.The patients received Gemcitabine 1000mg/ m 2 on d1,8,15 and HD-DDP 80-100mg/ m2 on d1 of 4 weeks regimen. All patients received at least two cycles of the treatment. Results Tw enty six of all the cases could be evaluated.The total response rate (RR) was 4 6.2%,The RR of 14 the first treatment patients was 57.1%.The RR of 12 recurrent patients were 33.3%.The major side effects were neutropenia,nausea vomiting,the other toxicity were mild and tolerable. Conclusion The c ombination of Gemcitabine and HD-DDP is an effective and tolerable regimen in th e treatment of ANSCLC.It could be considered as one of the standard therapies.
Keywords:Gemcitabine  HD-DDP  advanced non-small-cell lung canc er  combination chemotherapy
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