端粒／端粒酶系统与人类造血细胞

人类造血细胞与大多数体细胞一样，其端粒也随着细胞的每次分裂而不断丧失，因此不同发育阶段的造血细胞以及不同分化阶段的造血细胞其端粒的平均长度是不同的，并显示出相应不同的增殖和分化潜能与支持造血能力。端粒酶虽然在某种程度上能延缓造血干细胞自身端粒缩短的速度，但决不能完全阻止其丢失，并且正常造血细胞与恶性血液肿瘤细胞的端粒长度及其端粒酶活性也存在着明显的差异。这些发现为更深入地探讨正常造血细胞增殖、分化、成熟和凋亡的调控机制以及恶性血液肿瘤的发病机理、诊断和治疗的新策略研完提供了重要的理论依据。

Telomere/Telomerase System and Human Hematopoietic Cells

Human hematopoietic stem cells, like most somatic cells, lose telomeric DNA upon each cell division, so hematopoietic cells in different stage of development show various telomere length, and then display various pro-liferative potential and repopulation ability. Moreover, the malignant hematopoietic cells also show significantly shorter telomere and higher telomerase activity than those in the normal hematopoietic cells. These findings have implications for the control mechanism of primitive hematopoietic cells' proliferation, differentiation, maturation and apoptosis, and could provide certain theoretical foundation for researching the pathogenesis, diagnosis and a new therapy strategy for malignant hematopoietic diseases.