蒙古族及汉族胃癌患者血清胃蛋白酶原水平的研究

目的：研究蒙古族、汉族胃癌患者血清胃蛋白酶原（Pepsinogen PG）水平,探讨血清PG的地域和民族特征及规律,提供有价值的临床流行病学资料。方法：选择2008年10月~2009年10月在包头市肿瘤医院经内镜检查和病理学确诊的胃癌患者68例（3代人均为同一民族,蒙古族30例,汉族38例）,选择42例健康体检者做正常对照组。应用酶联免疫方法进行血清PGⅠ、PGⅡ的检测,并计算PGⅠ/PGⅡ比值。结果：蒙古族、汉族胃癌组血清PGⅠ及PGⅠ/PGⅡ值明显低于正常对照组,具有显著性差异（P〈0.05）,各组血清PGⅡ水平之间无显著性差异（P〉0.05）;蒙古族胃癌组血清PGⅠ及PGⅠ/PGⅡ值低于汉族胃癌组,具有显著性差异（P〈0.05）,两组血清PGⅡ水平之间无显著性差异（P〉0.05）。结论：蒙古族、汉族胃癌患者血清PGⅠ及PGⅠ/PGⅡ值较正常对照组降低,提示血清PGⅠ及PGⅠ/PGⅡ值降低有助于胃癌的诊断,可以作为地区人群筛查和辅助诊断胃癌的一项血清学指标;蒙古族胃癌患者血清PGⅠ及PGⅠ/PGⅡ值低于汉族胃癌患者,提示血清PG水平在不同种族人群中存在着差异。

Study on the Serum Pepsinogen Level in Mongolian And Han Chinese Patients with Gastric Cancer

Objective：To investigate association between Pepsinogen（PG）level in Mongolian and Han Chinese patients with gastric cancer,explore the geographical and ethnic characterristics,providing valuable clinical epidemiological study.Methods：Random choose 68 cases of gastric cancer patients diagnosed by endoscopy and pathology from october 2008 to october 2009 in Baotou Tumor Hospital,（3 on behalf of the per capita for the same nation,Mongolian 30 cases,Han 38 cases）, and there were 42 cases in the health.The concentrations of serum PGⅠ and PGⅡ in subjects,which were detocted Enzyme-linked immunosothent assay.Results：Serum PGⅠ level and PGⅠ / PGⅡ ratio of Mongolian and Han patients with gastric cancer was significantly lower than the normal group（P 0.05）,in statistics had significance,the changes of Serum PGⅡ level was not significant（P0.05）;Serum PGⅠ level and PGⅠ / PG Ⅱ ratio of Mongolian of gastric cancer patients were significantly lower than Han gastric cancer patients（P0.05）,in statistics had significance,the changes of serum PGⅡ level was not significant（P0.05）.Conclusion：The serum PGⅠ and PGⅠ/PG Ⅱ ratio subtypes were closely correlated with gastric disease,decreasing of PGⅠ and PGⅠ/PGⅡ ratio,which can be used as a serologic marker to serene and to help diagnosing gastric cancer;The serum PGⅠ and PGⅠ / PG Ⅱ ratio of Mongolian patients with gastric were lower than the Han Chinese patients with gastric cancer,the serum PG level had obvious difference in eating habits in different ethnic populations.