| 尼可地尔合用KB-R7943对缺血再灌注损伤离体大鼠心脏的保护作用 |
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| 引用本文： | 贾大林,李晓慧,姚维凡,邓立菊,于兆进,魏敏杰.尼可地尔合用KB-R7943对缺血再灌注损伤离体大鼠心脏的保护作用[J].中国新药与临床杂志,2011(1). |
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| 作者姓名： | 贾大林 李晓慧 姚维凡 邓立菊 于兆进 魏敏杰 |
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| 作者单位： | 中国医科大学附属第一医院心内科;中国医科大学药理教研室;辽阳石化总医院; |
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| 基金项目： | 辽宁省科学技术基金项目(2006401013-1) |
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| 摘 要： | 目的研究ATP敏感性钾通道开放药尼可地尔合用钠钙交换阻滞药KB-R7943对缺血再灌注损伤离体大鼠心脏的作用。方法离体大鼠心脏通过改良Langendorff装置灌流,减少灌流量造成缺血45 min后再灌注2 h建立大鼠心肌缺血再灌注损伤模型,分模型组、尼可地尔组、KB-R7943组、尼可地尔+KB-R7943组,每组10只。TTC染色观察心肌梗死面积,比色法检测冠脉灌流液中过氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,电镜观察心肌超微结构。结果与模型组比较,尼可地尔组和KBR7943组的心肌梗死面积均减小、冠脉灌流液中SOD活性升高、MDA含量下降(P<0.05);与模型组相比,尼可地尔+KB-R7943组的心肌梗死面积、冠脉灌流液中SOD活性和MDA含量改变均非常显著(P<0.01),心肌超微结构损伤减轻,均较尼可地尔组和KB-R7943组有显著改善(P<0.05)。结论尼可地尔合用KB-R7943可显著缩小心肌梗死面积,提高冠脉灌流液中SOD活性,减少MDA含量,减轻心肌超做结构损伤,对缺血再灌注损伤大鼠心脏有保护作用。
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| 关 键 词： | 心肌梗死 尼可地尔 KB-R7943 心肌再灌注损伤 钠钙交换蛋白 |
Protective effects of nicorandil combined with KB-R7943 on myocardial ischemia-reperfusion injury in isolated rat hearts |
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| JIA Da-lin,LI Xiao-hui,YAO Wei-fan,DENG Li-ju,YU Zhao-jin,WEI Min-jie.Protective effects of nicorandil combined with KB-R7943 on myocardial ischemia-reperfusion injury in isolated rat hearts[J].Chinese Journal of New Drugs and Clinical Remedies,2011(1). |
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| Authors: | JIA Da-lin LI Xiao-hui YAO Wei-fan DENG Li-ju YU Zhao-jin WEI Min-jie |
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| Institution: | JIA Da-lin~1,LI Xiao-hui~(2,3),YAO Wei-fan~2,DENG Li-ju~1,YU Zhao-jin~2,WEI Min-jie~2 (1.Department of Cardiology,the First Hospital of China Medical University,Shenyang LIAONING 110001,China,2.Department of Pharmacology,China Medical University,3. General Hospital of Liaoyang Petrochemical Corporation,Liaoyang LIAONING 111000,China) |
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| Abstract: | AIM To study the protective effects of ATP-sensitive K~+ channel(K_(ATP) channel) opener, nicorandil,combined with Na~+/Ca~(2+) exchange blocker,KB-R7943,on myocardial ischemia-reperfusion injury in isolated rat hearts.METHODS The isolated rat hearts were mounted on modified Langendorff apparatus.The rat myocardial ischemia-reperfusion injury model was established by 45-minutes ischemia followed by 2-hours reperfusion.The rats were divided into model group,nicorandil group,KB-R7943 group and nicorandil/KB-R... |
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| Keywords: | myocardial infarction nicorandil KB-R7943 myocardial reperfusion injury sodiumcalcium exchanger |
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