Preliminary experimental study on splenic hemodynamics of radiofrequency ablation for the spleen |
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| Authors: | Yasutaka Baba Sadao Hayashi Kohei Nagasato Michiyo Higashi Takashi Yoshiura |
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| Institution: | 1. Department of Radiology, Kagoshima University, Kagoshima, Japan;2. Department of Diagnostic Radiology, Hiroshima University, Hiroshima, Japan;3. Department of Human Pathology, Kagoshima University, Kagoshima, Japan |
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| Abstract: | Purpose: To test the splenic blood flow change after radiofrequency ablation (RFA) of the spleen in a porcine experimental model.Material and methods: Six pigs underwent RFA of the spleen via laparotomy. During the procedure of RFA, clamping of splenic artery (one) and both splenic artery/vein (one) was also performed. Measurement of blood flow of both splenic artery (SA) and splenic vein (SV) with flow-wire at pre- and post-RFA of the spleen was also performed.Results: Ablated splenic lesions were created as estimating ～50% area of the spleen in all pigs. Resected specimens reveal not only the coagulated necrosis but also the congestion of the spleen. On the SA hemodynamics, maximum peak velocity (MPV) changed from 37?±?7?to 24?±?8?cm/s (normal), 11?to 10?cm/s (clamp of the SA), and 12?to 7.5?cm/s (clamp of both SA/SV), respectively. On the SV hemodynamic, MPV changed from 15?±?5?to 13?±?4?cm/s (normal), 17?to 15?cm/s (clamp of the SA), and 17?to 26?cm/s (clamp of both SA/SV), respectively.Conclusions: RFA of the spleen could induce coagulation necrosis and reduce the splenic arterial blood flow. |
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| Keywords: | Portal hypertension hypersplenism radiofrequency ablation |
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