先天性唇腭裂发病危险因素的Logistic回归分析

目的 探讨先天性唇腭裂（cleft lip and palate,CLP）的发病危险因素。方法 对189例 CLP患儿的母亲及60例非CLP患儿的母亲进行成组病例对照研究,调查内容包括可能引起CLP发生的危险因素,用非条件Lo-gistic回归方法进行单因素和多因素分析。结果 单因素分析显示与唇裂伴或不伴腭裂（CL ± P）发病有显著性意义的因素共8种,最终进入多因素Logistic回归模型的变量有家族史、O型血、出生季节（5月～7月）和母亲职业:与腭裂（CP）发病有显著性意义的因素共4种,进入多因素 Logistic回归模型的变量为胎次、出生季节（11月～次年1月）和母亲职业。结论 环境和遗传因素是CL±P的主要发病因素,而CP则主要与环境因素有关。

A LOGISTIC REGRESSION ANALYSIS ON RISK FACTORS AND CLEFT LIP AND PALATE

ve To study the risk factors in the occurrence of cleft lip and palate (CLP). Methods 189 CLP mothers and 60 normal mothers were studied in a case-control study. The investigation included the risk factors which may cause CLP. Nonconditional stepwise logistic model to simple factor and multivariate analysis was used. Results According to simple factor analysis, 8 factors were significantly related with cleft lip with or without palate (CL ± P)and 4 factors related with cleft palate (CP) . In the multiple logistic regression model, only family history, blood type(O), birth season (May -July ) and mother occupation were related with CL ± P and only number of pregnance, birth season (November - January) and occupation related with CP, Conclusion Hereditary and environmental factors may be the risk factors for occurrence of CL ± P, but only environmental factor is the risk factor for occurrence of CP.