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| 培氟沙星的抗生素后效应 | |
| 引用本文： | 王中孝,方翼,苏林光,罗琳,王睿.培氟沙星的抗生素后效应[J].中国医药导刊,2002,4(4):290-291. |
| 作者姓名： | 王中孝 方翼 苏林光 罗琳 王睿 |
| 作者单位： | 1. 解放军总医院临床药理研究室,北京,100853 2. 海南省人民医院 3. 西双版纳人民医院 |
| 摘 要： | 目的:研究新喹诺酮类药物培氟沙星(Pefloxacin,PFLX)的抗生素后效应(PAE)。方法:应用AVANTAGE自动微生物分析仪的光密度法测定培氟沙星的抗生素后效应。结果:PFLX金黄色葡萄球菌、表皮葡萄球菌和铜绿假单胞菌均产生明显的PAE,PAE随抗菌药物浓度增大而延长,除在4×MIC与8×MIC时,PFLX对金黄色葡萄球菌的PAE无显著性差异外,其余各药物浓度间的PAE有显著性差异(P<0.05),并呈浓度依赖性关系。结论:PFLX均产生明显的PAE,呈现明显的剂量依赖性,对于临床合理应用PFLX具有重要实际意义。 |
| 关 键 词： | 抗生素后效应 培福沙星 光密度法 |
The Postantibiotic Effects of Pefloxacin |
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| Wang Zhong - xiao,Fang Yi,Shu Lin - guang,et al..The Postantibiotic Effects of Pefloxacin[J].Chinese Journal of Medicinal Guide,2002,4(4):290-291. | |
| Authors: | Wang Zhong - xiao Fang Yi Shu Lin - guang |
| Abstract: | Objective: To study on the post - antibiotic effect (PAE) of the new fluoquinolone pefloxacin(PFLX) .Methods: The PAE was determined by the spectrophotometric method using AVANTAGE Microbiology System. Results: PFLX against Staphylococ-cus aurus, Staphylococcus epidermidis and Pseudomonas aeruginosa of PAE were 0. 9h, 0.81h and 0.85h, respectively. Marked PAE were induced depended on the concentration of the drugs. Conclusion: PAEs induced by PFLX were obvious and depended on the dose of the drugs. It should be considered as a important factor in designing dosing schedule of the drugs. |
| Keywords: | PAE PFLX spectrophotometric method |
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