| 窒息对鼠脑分泌组织型纤溶酶原激活物的影响 |
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| 引用本文： | 徐剑文,王玮,康仲涵,赵小贞,张更.窒息对鼠脑分泌组织型纤溶酶原激活物的影响[J].中国组织工程研究与临床康复,2001,25(18):144. |
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| 作者姓名： | 徐剑文 王玮 康仲涵 赵小贞 张更 |
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| 作者单位： | 徐剑文（Fujian Medical University， Fuzhou 350004,China）
王玮（Fujian Medical University， Fuzhou 350004,China）
康仲涵（Fujian Medical University， Fuzhou 350004,China）
赵小贞（Fujian Medical University， Fuzhou 350004,China）
张更（Fujian Medical University， Fuzhou 350004,China） |
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| 摘 要： |
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| 修稿时间： | 2001年6月1日 |
Influences on the activities of tissue- type plasminogen activator of mouse brain in asphyxia |
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| Abstract: | Objective To observe the changes of the activity of tissue－type plasminogen activator(TPA) after asphyxia. Methods Asphyxia was induced in mouse pups by performing a‘ delayed cesarean section' . The experiment was designed for a control group and 4 asphyctic groups to detect the activity of TPA. Results TPA activity of brain increased after asphyxia (P<0.01). Conclusion TPA increased after asphyxia might be able to attack the basement membrane of microvessels, then opened the blood－brain barrier and induced neuronal damage. |
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| Keywords: | tissue- type plasminogen activator asphyxia brain perinatal |
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