| 垂体后叶素致肝纤维化作用研究 |
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| 引用本文： | 雷权,朱应康,范宇虹,赵海滨,卢桂凤,雷耀强,黄清莲,蒙佳莲,张自斌. 垂体后叶素致肝纤维化作用研究[J]. 中国现代药物应用, 2009, 3(4) |
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| 作者姓名： | 雷权 朱应康 范宇虹 赵海滨 卢桂凤 雷耀强 黄清莲 蒙佳莲 张自斌 |
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| 作者单位： | 南宁市邕宁区人民医院内二科,530200 |
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| 基金项目： | 南宁市科研与技术开发、创新计划自筹项目，南宁市邕宁区科研与技术开发项目 |
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| 摘 要： | 目的在肝硬化及肝癌患者中应用垂体后叶素,了解其致肝细胞凋亡,肝纤维化情况。方法垂体后叶素12U治疗21例肝硬化及肝癌患者,监测治疗前,用药30min时及用药结束时的谷丙转氨酶。以高于谷丙转氨酶正常值上限2倍以上为较严重肝损害。结果21例患者用药30min时及用药结束时,谷丙转氨酶升高均无超过未用药前的两倍以上者。结论垂体后叶素用药近期无较严重致肝细胞凋亡、肝纤维化的作用。垂体后叶素致肝细胞凋亡及肝纤维化的作用,仍待深入研究。
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| 关 键 词： | 垂体后叶素 肝纤维化 |
The role of pituitrin in liver fibrosis |
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| Affiliation: | LEI Quan; ZHU Ying-kang; FAN Yu-hong; et al.The People s Hospital of Yongning County; Nanning Guangxi; 530200; China; |
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| Abstract: | Objective Pituitrin was used in pateints with cirrhosis of liver or primary carcinoma of the liver,to observe whether it lead to liver fibrosis.Method 21 Liver fibrosis and liver carcinoma patients,received intravenous pituitrin at the dose of 12 U.Lab studies of ALT was assayed priror to and follwing pituitrin therapy 30 minutes and the later of the treatment finished.ALT ascending surpassed twice over as severe side effect of liver injured happened.Results None of the ALT ascending surpassed twice over as... |
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| Keywords: | Pituitrin Liver fibrosis |
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