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| 引用本文： | 周频,何庆南,谭爱斌,李晓燕,姜莹,黄爱文,易著文. ������ҩ�������ۺ�����С����Ƥϸ��-�����ת���ٴ������о�[J]. 中国实用儿科杂志, 2010, 25(3): 191 |
| 作者姓名： | 周频 何庆南 谭爱斌 李晓燕 姜莹 黄爱文 易著文 |
| 作者单位： | ?????????????С???????о?????????410011 |
| 基金项目： | 中南大学研究生教育创新工程项目资助(项目编号:2340-77306) |
| 摘 要： | 目的探讨肾小管上皮细胞-间充质转化(EMT)与肾脏病理进展及原发性肾病综合征(INS)糖皮质激素(GC)耐药的关系。方法2005年9月至2007年12月在中南大学湘雅二医院儿科住院行肾穿刺活检的INS患儿40例,分为激素耐药性肾病综合征(SRNS)组(20例)和激素敏感性肾病综合征(SSNS)组(20例)。免疫组化双染法检测INS患儿和5例正常对照组儿童肾组织中细胞角蛋白(CK)和波形蛋白(vimentin)的表达,肾脏病理评分半定量评价肾组织病理损害程度。结果SRNS组肾小管-间质病理评分显著高于SSNS组(P<0.05);正常对照组肾小管上皮细胞内只表达CK,不表达vimentin;INS肾小管上皮细胞均不同程度表达vimentin;SRNS组肾组织CK表达较SSNS组显著降低[分别为(66.25±12.13)%和(76.64±7.64)%,P<0.05],vimentin表达较SSNS组显著增高[分别为(11.51±7.48)%和(4.98±2.27)%,P<0.05];不同肾小管-间质病变(轻、中、重度)组肾小管上皮细胞内CK和vimentin表达量的差异均有统计学意义[CK表达量分别为(79.97±... |
| 关 键 词： | ???????????????????????ε???????????? |
Significance of epithelial to mesenchymal transition in children with steroid-resistant nephrotic syndrome |
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| ZHOU Pin,HE Qing-nan,TAN Ai-bin,LI Xiao-yan,JIANG Ying,HUANG Ai-wen,YI Zhu-wen.Laboratory of Pediatric Nephrology,the Second Xiangya Hospital of Central South University,Changsha ,China. Significance of epithelial to mesenchymal transition in children with steroid-resistant nephrotic syndrome[J]. Chinese Journal of Practical Pediatrics, 2010, 25(3): 191 | |
| Authors: | ZHOU Pin HE Qing-nan TAN Ai-bin LI Xiao-yan JIANG Ying HUANG Ai-wen YI Zhu-wen.Laboratory of Pediatric Nephrology the Second Xiangya Hospital of Central South University Changsha China |
| Affiliation: | Laboratory of Pediatric Nephrology?? the Second Xiangya Hospital of Central South University?? Changsha 410011?? China |
| Abstract: | Objective To study the relationship of epithelial to mesenchymal transition with renal pathological progression and slucocorticoid resistance in idiopathic nephrotic syndrome.Methods The different expressions of CK and vimentin were detected with the immunohistochemistry double staining technique in renal biopsy tissues obtained from 20 SRNS children,20 SSNS children and 5 nephrectomized healthy children,respectively.Renal histopathological lesion was evaluated by the semi-quantitative counting scores.Resul... |
| Keywords: | nephrotic syndrome cytokeratin vimentin glucocorticoid |
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