血浆纤维蛋白原在冠心病发生发展中意义的研究

目的:探讨血浆纤维蛋白原(FBG)在冠心病(CHD)发生发展中所起的作用。方法:疑为CHD的病人220例,根据冠状动脉造影和临床生化指标分为急性心肌梗死(AMI)组、稳定型心绞痛(SAP)组、正常组。空腹抽取静脉血2ml,应用散射比浊法测定血浆FBG水平。常规空腹抽血检测血糖血脂。结果:AMI组血浆FBG浓度明显高于SAP组及正常组(P<0.05),SAP组血浆FBG浓度明显高于正常对照组(P<0.05),而且血浆FBG浓度与冠脉病变程度高度相关。结论:FBG可能参与了冠心病的病理变化,特别是心肌梗死,影响疾病的发生与发展。

Significance of plasma fibrinogen in the occurrence and development of coronary heart disease

Objective:To explore the role of plasma fibrinogen in the occurrence and development of coronary heart disease (CHD). Methods:According to the results of coronary angiography and clinical biochemical examination,220 patients with suspected CHD were divided into acute myocardial infarction(AMI) group(n=74),stable angina pectoris(SAP)group(n=76),and normal control group(n=70). The levels of plasma fibrinogen,blood glucose,and blood lipid were measured. Results:The level of plasma fibrinogen was significantly higher in AMI group than in SAP and normal control groups(P < 0.05),and it was significantly higher in SAP group than in normal control group(P < 0.05). The level of plasma fibrinogen was closely correlated with the degree of coronary stenosis. Conclusion:Plasma fibrinogen may be involved in the occurrence and development of CHD,especially AMI.