Atypical carcinoid of thymus associated with multiple endocrine neoplasia syndrome type 1 |
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Authors: | Yosuke Otake Minoru Aoki Takao Nakanishi Kimio Hashimoto |
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Institution: | (1) Department of Nuclear Medicine, Erasmus MC, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands;(2) Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands |
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Abstract: | Thymic carcinoid associated with multiple endocrine neoplasia syndrome type 1 (MEN-1) is a rare tumor. We report a case of
MEN-1-related thymic carcinoid. The patient reported herein had already been diagnosed with MEN-1 and was found to have a
mediastinal mass. She underwent thymectomy with partial resection of the left innominate vein and lung. Histological examination
revealed atypical carcinoid with infiltration. MEN-1 gene mutation was detected by employing the direct nucleotide sequencing
method. Postoperative 2-fluoro-2-deoxyglucose positron emission tomography showed probable multiple metastases in the vertebrae
and myocardium. However, she has been alive and asymptomatic for 2 years postoperatively. MEN-1-related thymic carcinoid is
often insidious with a poor prognosis. We suggest chest computed tomography scan or magnetic resonance imaging for MEN-1 patients
and serological or genetic screening for patients with thymic carcinoid to screen for MEN-1. |
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