Hematopoiesis from pluripotent stem cell lines |
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Authors: | Hiroshi Sakamoto Kiyomi Tsuji-Tamura Minetaro Ogawa |
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Institution: | (1) Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan |
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Abstract: | Embryonic stem cells (ESCs) can differentiate into various types of hematopoietic cells (HPCs) when placed in an appropriate
environment. Various methods for the differentiation of ESCs into specific HPC lineages have been developed using mouse ESCs.
These ESC-differentiation methods have been utilized also as an in vitro model to investigate hematopoiesis in embryos and
they provided critical perceptions into it. These methods have been adapted for use with human ESCs, which have the possibility
of being employed in regenerative medicine; further improvement of these methods may lead to the efficient production of HPCs
for use in transfusions. The generation of transplantable hematopoietic stem cells is a medical goal that is still difficult
to achieve. Recently, induced pluripotent stem (iPS) cells have been established from differentiated cells. Thereby, iPS cells
have expanded further possibilities of the use of pluripotent stem cell lines in clinical application. Indeed, iPS cells have
been established from cells with disease genes and those which have undergone reprogramming and targeting have generated phenotypically
normal HPCs. Here, we mainly summarize the recent progress in research on hematopoiesis conducted with ESCs and iPS cells. |
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