TA方案和NP方案治疗晚期乳腺癌临床研究

目的：观察比较紫衫醇＋表阿霉素（TA）和长春瑞滨＋顺铂（NP）两种化疗方案治疗晚期乳腺癌的疗效和毒性.方法：46例晚期乳腺癌患者随机分为TA组和NP组,每组23例.TA组紫杉醇135 mg/m^2,第1天;表阿霉素25 mg/m^2 ,第2～3天.NP组长春瑞滨40 mg/m^2,第1天、第8天;顺铂25 mg/m^2, 第1～4天. 结果：疗效按WHO标准,TA组总有效率65.2%,NP组总有效率为56.5%,两组间比较差异无统计学意义（P＞0.05）.主要毒副反应中,骨髓抑制、恶心呕吐、脱发,两组间差异无统计学意义（P＞0.05）;TA组的关节肌肉酸痛发生率（39.1%）高于NP组（4.3%）,NP组的静脉炎发生率（43.5%）,明显高于TA组（8.7%）,组间比较均有统计学意义 （P＜0.05）.结论：TA和NP两组方案治疗复发转移性乳腺癌疗效高且无统计学差别,均可作为治疗晚期乳腺癌的有效方案.

Clinical Review of TA and NP in Treatment of Advanced Breast Cancer

Objective：To evaluate the efficacy and toxicity of TA and NP in the treatment of advanced breast cancer. Methods： Forty - six patients were allocated to the TA group （ pacfitaxel ＋ Epirubiei ） and the NP group （vinorelbine ＋ cisplatin）. 23 patients received TA（ PTX 135 mg/m^2 on day 1 plus DDP 25 mg/m^2 on days 1 -2） ;23 patients received NP （vinorelbine 40mg/m^2 on days 1 ,days 8 ,cisplatin 25 mg/m^2 on daysl -3）. Results：In TA group,the response rate was 65.2%. In NP group,the response rate was 56.5%. The efficacy was not significantly different between the two groups（ P 〉 0.05 ）. The main toxicity was not significantly different between the two groups（P 〉 0.05） , include leukopenia,gastroenteric reaction and alopecia, but TA group（ 39. 1% ） was higher than the NP group （4.3%） in muscle and skeletal pain. There were significant difference between the two groups（P 〈 0.05） ;NP group（43.5% ） was higher than the TA group（8.7% ） in phlebitis. There were significant difference between the two groups （ P 〈 0.05 ）. Conclusions： Both therapies are effective for advanced breast cancer and the response rate is no significant difference.