最大呼气肺功能测定对小气道早期病变和慢性阻塞性肺病的应用价值

对正常不吸烟者45例、无症状吸烟者44例、慢支20例、轻度肺气肿34例、中重度肺气肿23例进行最大呼气肺功能测定。结果显示,正常不吸烟组和无症状吸烟组之间FEF_(25-75％)差异显著(P<0.05),V_(50)差异非常显著(P<0.01);无症状吸烟者的异常检出率分别为22.7％和20.5％,表明可作为检出小气道早期病变的指标。三组慢阻肺病人之间FEV_1％和V_(75)的差异均有非常显著意义(P<0.01);异常检出率随病情演变而递增,提示对慢阻肺病变程度的判断有一定价值。

THE CLINICAL EVALUATION OF PULMONARY FUNCTION TESTS FOR MAXIMUM EXPIRATION IN SMALL-AIRWAY DISEASES AND CHRONIC OBSTRUCTIVE PULMONARY DISEASES

The pulmonary function tests for maximal expiration were taken in 45 normal nonsmokers, 44 asymptomatic smokers, 20 cases with chronic bronchitis, 34 cases with mild emphysema and 23 cases with moderate and severe emphysema. Mean value of FEF 25-75 per cent is significantly different ( P <0.05 ) and V50 is very significantly different ( P <0.01 ) between normal nonsmokers and asymptomatic smokcrs; the identifying abnormalities of them in asymptomatic smokers are 22.7 per cent and 20.5 per cent respectively and show to be selective as detecting indices of early small airway diseases. The differences of FEV 1 per cent and V75 between each two of the three groups with COPD are very significant ( P <0.01 ) ; the indentifying abnormalities correlate with the development of the diseases and indicate they are helpful to the determination of the lesion degrees of chronic obstructive 'pulmonary diseases.