毒毛旋花子苷K间歇疗法治疗冠心病心力衰竭的临床研究

目的 :评价毒毛旋花子K间歇疗法 (简称ISKT)治疗保持窦性心律的冠心病心力衰竭的疗效及可行性。方法 :2 0 0例窦性心律的冠心病心力衰竭患者分为两组 :A组 98例采用维持量地高辛治疗 ;B组 10 2例采用ISKT。结果 :心率 (HR)、左室射血分数 (LVET)及血压 (BP)治疗前与治疗后 3个月比较 ,在A组分别为 :88± 12及 6 8± 12 (次 /min ,P <0 .0 1) ;0 32± 12及 0 40± 12 (P <0 .0 1) ;12 6± 2 1/ 90± 6及 12 8± 2 1/ 80± 15 ,(mmHg,P >0 .0 5 ) ;在B组分别为 :90± 10及 70± 11(次 /min ,P <0 .0 1) ;0 .32± 0 .10及 0 48± 0 10 (P <0 .0 1) ;12 8± 2 0 / 91± 7及 110± 10 / 76± 10(mmHg ,P <0 .0 1)。治疗 3个月后两组间比较 :HR(P >0 .0 5 ) ;LVEF(P <0 .0 5 ) ,Bp(P <0 .0 0 1)。B组的心功能有较好的改善 ,因心绞痛而服用的硝酸甘油量较少 ,两组洋地黄中毒或过量发生率的差别无显著性的意义。结论 :对窦性心律的冠心病心力衰竭 ,ISKT是安全、有效、可行的一种治疗方法。

Clinical evaluation of intermittent strophanthin K therapy for congestive heart failure combined coronary artery disease

Objective To evaluate the effects and safety of intermittent strophanthin K therapy (ISKT) for congestive heart failure combined coronary artery disease with sinus rhythm. Methods Two hundred patients divided into Group A (98 cases with maintenance digoxin therapy) and Group B (102 cases with ISKT). They were studied for 3 months and some of them for longer period. Results Comparing the pretreatment data: ①heart rate (HR, bpm), ②left ventricular ejection fraction (LVEF), ③blood pressure (Bp, mmHg, calculated values as mean Bp for statistics). In group A, item①and ② were significantly improved (item ①88±12 and 68±12, P<0.01; item ② 0.32±0.12 and 0.40±0.12, P<0.01; item ③ showed no significant difference (126±21/90±6 and 128±21/80±5,P>0.05). In group B, item ①,② and ③ were significantly improved (item①90±10 and 70±11, item②0.32±0.10 and 0.45±0.10, item③128±±20/91±7 and 110±10/76±10, the p valves are the same <0.01). As compared with the posttreatment data of both group A and B, HR, P>0.05, there was no significant difference, LVEF, P<0.05, there was significant difference, Bp, P<0.01, there was significant difference. It showed no significant difference in total occurrence rate of digitalis overload or toxication between two groups also. Conclusion ISKT for congestive heart failure combined coronary artery disease with sinus rhythm is effective and safe, with better improvement of heart function and Bp leve.