类风湿性关节炎患者杀伤细胞免疫球蛋白样受体基因多态性分析 |
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引用本文: | 孙浩,李丽,樊卫民,施妍,何成涛,崔燕.类风湿性关节炎患者杀伤细胞免疫球蛋白样受体基因多态性分析[J].现代医学仪器与应用,2010(1). |
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作者姓名: | 孙浩 李丽 樊卫民 施妍 何成涛 崔燕 |
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作者单位: | 东南大学临床医学院检验系;东南大学附属中大医院临床免疫室; |
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基金项目: | 国家大学生创新性实验计划项目(G2007058); 江苏省科技厅社会发展基金项目(BS2006542); 江苏省卫生厅科学技术项目(H200757) |
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摘 要: | 目的分析类风湿性关节炎(rheumatoid arthritis,RA)患者杀伤细胞免疫球蛋白样受体基因多态性,探讨其与类风湿性关节炎发病之间的关联。方法采用序列特异性引物聚合酶链反应(PCR-SSP)法,分析90例RA患者和200例健康对照组KIR基因。结果通过对RA病例组与正常对照组的9种KIR基因的分析,比较其基因频率发现:RA病例组KIR2DS4的基因频率显著低于对照组(P<0.05),差异具有统计学意义;其余各基因频率与对照组相比,P>0.05,差异无统计学意义。结论RA患者KIR2DS4基因可能与RA发病有关。
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关 键 词: | 杀伤细胞免疫球蛋白样受体(KIR) 类风湿关节炎(RA) 基因多态性 序列特异性引物聚合酶链反应(PCR-SSP) |
Investigation of the killer cell immunoglobulin-like receptors gene polymorphisms of patients with rheumatoid arthritis |
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Authors: | SUN Hao LI Li FAN Weimin SHI Yan HE Chengtao CUI Yan |
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Institution: | SUN Hao1,LI Li1,2,FAN Weimin1,SHI Yan1,HE Chengtao1,CUI Yan1(1.Department of Laboratory Medicine,Clinical Medical College,Southeast University,Jiangsu,Nanjing 210009,China,2.Department of Immunology Laboratory,Zhong Da Hospital,China) |
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Abstract: | Objective To investigate the association between the killer cell immunoglobulin-like receptors gene polymorphisms and rheumatoid arthritis(RA).Methods DNA samples of 90 RA patients and 200 controls were genotyped by PCR-SSP.Results The gene frequency of KIR2DSK in RA was significantly lower than that in controls(P<0.05).Conclusion KIR2DS4 gene may be associated with RA. |
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Keywords: | Killer cell immunoglobulin-like receptors(KIR) Rheumatoid arthritis(RA) Genotype polymorphism Polymerase chain reaction sequence-specific prime(rPCR-SSP) |
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