A new syndrome of mental retardation and epilepsy characterized by dense microsphere accumulation |
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Authors: | D. H. George D. G. Munoz |
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Affiliation: | (1) Department of Pathology, Royal University Hospital, S7N OXO Saskatoon, Saskatchewan, Canada;(2) Department of Pathology (Neuropathology), University of Western Ontario, London, Ontario, Canada |
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Abstract: | Summary Dense microspheres (DMS) are enigmatic structures found within dendrites in the normal human cortex; their composition and function are unknown. We describe a case of a 29-year-old male with a history of mental retardation and epilepsy in whom the unique neuropathological finding was a marked excess of DMS, most notably in the neocortex. This is a previously undescribed neuropathological syndrome, and represents the first unequivocal association of DMS with a neurological disorder. |
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Keywords: | Epilepsy Mental retardation Dense microsphere |
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