Pharmacokinetics of dexamethasone in premature neonates |
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| Authors: | R. A. Lugo M. C. Nahata J. A. Menke E. McClead |
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| Affiliation: | (1) The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210 Columbus, Ohio, USA;(2) Present address: College of Pharmacy, University of Utah, Salt Lake City, Utah, USA |
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| Abstract: | Objective: Dexamethasone is frequently used in premature neonates with bronchopulmonary dysplasia, however little is known about its disposition in this population.Methods: We evaluated the pharmacokinetics of dexamethasone in 9 premature neonates with a mean gestational age of 27.3 weeks and a postnatal age of 21.8 days.Results: There was a strong relationship between clearance (4.96 ml·min–1·kg–1) and gestational age (r=0.884). Pharmacokinetic parameters were grouped based on a gestational age of less than 27 weeks (Group I) and greater than 27 weeks (Group II). Mean clearance in group I and group II was 1.69 and 7.57 ml·min–1·kg–1, respectively. Mean distribution volume in group I and II was 1.26 and 2.19 l·kg–1, respectively. No significant relationships were noted between the disposition of dexamethasone and ventilator requirements or adverse effects.Conclusion: The pharmacokinetics of dexamethasone in premature neonates was related to gestational age. |
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| Keywords: | Dexamethasone Premature neonates pharmacokinetics bronchopulmonary dysplasia infant newborn |
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