Effect of stobadine on stimulated isolated mast cells |
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| Authors: | K Drábiková J Pecivová R Nosál |
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| Institution: | Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia. |
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| Abstract: | Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells. |
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