Human NK cells: their ligands, receptors and functions |
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Authors: | Hugh Reyburn,Ofer Mandelboim,Mar Valé s-Gomé z,Eric G. Sheu,Laszio Pazmany,Daniel M. Davis,Jack L. Strominger |
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Affiliation: | Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA. |
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Abstract: | Summary: The expression, or lack thereof, of class I MHC glycoproteins has a marked influence on natural killer cell function. Cells which do not express class I MHC molecules are susceptible to lysis by NK cells, and transfection of these targets with class I MHC genes can render these cells resistant to NK attack. This inhibition of NK-killing is mediated by a novel family of receptors expressed mainly on NK cells, but also found on some T-cells. The function of these class I MHC binding receptors when expressed on T-cells is discussed also and a novel co-stimulatory activity of NKAR described. Lastly, a novel mechanism by which human cytomegalovirus evades immune surveillance by NK cells is documented. |
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