参桂胶囊辅助治疗重度充血性心力衰竭的临床疗效观察

目的:观察参桂胶囊辅助治疗重度充血性心力衰竭的临床疗效及安全性。方法:将重度充血性心力衰竭患者68例随机分为2组:对照组34例行常规治疗(休息、吸氧、强心、利尿、扩血管及对症等);观察组34例在常规治疗的基础上加用参桂胶囊,每次0.9g,每日3次。2组均4周为1疗程。监测2组患者用药前、后心率、血压、心电图、心脏彩超、血浆心钠素(ANF)、电解质、肌酐的变化情况。结果:参桂胶囊能较好改善心脏功能且降低血浆ANF水平,与对照组比较具有显著性差异(P<0.01)。结论:参桂胶囊辅助治疗重度充血性心力衰竭疗效较好,无明显毒副作用,可作为该症的常规治疗药物。

Clinical Study of Shengui Capsule as an Adjunctive Therapy for Severe Congestive Heart Failure

OBJECTIVE:To observe the clinical efficacy and safety of Shengui capsule in treating severe congestive heart failure(CHF).METHODS: 68 patients with severe CHF were randomly divided into 2 groups:34 patients(control group) were treated with routine therapy(rest,oxygen inhalation,inotropic agents and diuretic agents,vasodilators and symptomatic treatment) for 4 weeks,and another 34 patients with routine therapy plus 0.9 g Shengui capsule tid for 4 weeks(trial group).HR,BP,ECG,CD(Color Doppler),ANF(atrial natriuretic peptide),electrolytes and SCr before and after treatment were compared between the two groups.RESULTS: The cardiac function was improved and ANF level was down-regulated in patients treated with Shengui capsule,showing significant difference as compared with control group(P<0.01).CONCLUSION: Shengui capsule showed satisfactory efficacy but less side effect as an adjunctive therapy in patients with severe CHF,and it thus can be used as routine drug for severe CHF.