| 二磷酸盐对关节磨屑刺激单个核细胞表达IL-6m RNA的影响 |
| |
| 引用本文： | 陈明,夏仁云.二磷酸盐对关节磨屑刺激单个核细胞表达IL-6m RNA的影响[J].中国矫形外科杂志,2004,12(6):447-449. |
| |
| 作者姓名： | 陈明 夏仁云 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院骨科,武汉,430030 |
| |
| 摘 要： |
|
| 关 键 词： | 二磷酸盐 关节磨屑 白细胞介素—6 基因表达 |
| 文章编号： | 1005-8478(2004)06-0447-03 |
| 修稿时间： | 2003年10月20 |
Effect of bisphosphonates on IL-6mRNA expression of human monocytes induced by wear debris |
| |
| CHEN Ming,XIA Ren-yun.Effect of bisphosphonates on IL-6mRNA expression of human monocytes induced by wear debris[J].The Orthopedic Journal of China,2004,12(6):447-449. |
| |
| Authors: | CHEN Ming XIA Ren-yun |
| |
| Institution: | CHEN Ming,XIA Ren-yun.Department of Orthopaedics,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan430030 |
| |
| Abstract: | Objective:To study the mechanism of bisphosphonates in the prevention and treatment of aseptic loosening of prosthesis on cytokines-related genes modulation.Methods:In vitro human peripheral blood mononuclear cells(PBMC) were cultured with wear particles and sodium allendronate of different concentration.Then expression of IL-6m RNA was determined by In Situ Hybridization and RT-PCR techniques.Results:The expression of IL-6mRNA was increased significantly when wear particles was added as compared with control group ( P <0.01).Hybridization and RT-PCR demonstrated that bisphosphonates reduced IL-6mRNA expression.Conclusion:Wear debris can stimulate IL-6mRNA expression of human PBMC.Bisphosphonates may be used in the prevention and treatment of aseptic loosening of prosthesis by downregulating IL-6mRNA expression of human PBMC. |
| |
| Keywords: | Allendronate Wear debris Interleukin-6 Gene expression |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
