| 银屑病中细胞凋亡相关基因bcl-2、Fas、bax的检测 |
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| 引用本文： | 徐娟,贾随旺,郑茂荣,方跃明,孙君红.银屑病中细胞凋亡相关基因bcl-2、Fas、bax的检测[J].临床皮肤科杂志,2000,29(2):79-81. |
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| 作者姓名： | 徐娟 贾随旺 郑茂荣 方跃明 孙君红 |
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| 作者单位： | 1. 第二军医大学长海医院皮肤科,上海市,200433
2. 广州南方医院 |
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| 摘 要： | 为了细胞凋亡相关基因ｂｃｌ－２、Ｆａｓ、ｂａｘ在银屑病发病中的意义，采用免疫组化ＡＢＣ法、ＳＡＢＣ法检测了这几种基因在１５例银屑病中的表达。结果发现银屑病的角质形成细胞中抑凋亡基因ｂｃｌ－２几乎不表达，促凋亡基因Ｆａｓ、ｂａｘ阳性表达。揭示促凋亡基因Ｆａｓ、ｂａｘ在银屑病中发病起重要作用，而抑凋亡基因ｂｃｌ－２作用可能不大。
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| 关 键 词： | 银屑病 bcl－2基因 Fas基因 bax基因 |
Detection of apoptotic related gene bcl- 2,Fas, bax in psoriasis |
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| Xu Juan,Jia Suiwang,Zheng maorong,Fang Yaoming,Sun junhong.Detection of apoptotic related gene bcl- 2,Fas, bax in psoriasis[J].Journal of Clinical Dermatology,2000,29(2):79-81. |
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| Authors: | Xu Juan Jia Suiwang Zheng maorong Fang Yaoming Sun junhong |
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| Abstract: | In order to explore the importance of the apoptotic related gene bcl 2,Fas, bax in pathogenesis of psoriasis, these genes were detected in 15 psoriasis patients by using immunohistochemical staining ABC and SABC methods We found the suppressing apoptosis gene bcl 2 scarcely revealed positive result in keratinocytes of psoriasis, but promoting apoptosis gene fas and bax revealed positive reactivities This indicated that the promoting apoptosis gene Fas and bax were very important in the pathogenesis of psoriasis, but the function of suppressing apoptosis gene bcl 2 may be not very prominent |
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| Keywords: | Psoriasis\ bcl 2 gene\ Fax gene\ bax gene |
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