肾集合管癌2例病理诊断及文献复习

目的 探讨起源于肾髓质集合管的肾集合管癌，分析其病理形态学特征及鉴别诊断。方法 对2例肾集合管癌进行大体、光镜及免疫组化观察并结合文献复习。结果肿瘤主要位于肾髓质，囊实性肿块，呈灰白或灰黄色，侵袭性强。镜下肿瘤呈弥漫性或腺管状,乳头状排列,肿瘤间质纤维组织反应性增生，多量浆细胞、淋巴细胞浸润。免疫组化：肿瘤细胞高分子CK、低分子CK表达阴性,Vimetin强阳性。结论 肾集合管癌是一种起源于肾髓质集合管的罕见性肾肿瘤，恶性度高，预后差。

Collecting duct carcinoma of kidney: two case report and literature review

Objective To discuss the histological features and differential diagnosis of collecting duct carcinoma (CDC) which occurred in the medulla of the kidney. Methods Two cases of CDC were analyzed grossly light microscopically and immunohistochemically. Results The primary tumor was located predominantly in the renal medulla cyst-read lump. Pathological histology showed the tumor cells displayed diffuse tubular, tubular-papillary patterns with a proliferative lyalinizing stroma and a large number of plasmacyte and lymphoid cells infiltration. Immuniohistochemically, the tumorous cells displayed negative for CK(AE3/AE1), but positive for vimetin. Conclusion CDC is a rare neoplasm arising from the medullar collecting ducts , and it pursues more aggressive course with poor prognosis.