Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia |
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Authors: | Ikeya Yukinobu Takeda Shigefumi Tunakawa Mitsuo Karakida Humito Toda Kouin Yamaguchi Takuji Aburada Masaki |
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Institution: | Research Division, Tsumura & Co., Ibaraki, Japan. ikeya_yukinobu@mail.tsumura.co.jp |
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Abstract: | We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia Willdenow, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of P. tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound 1 has cognitive improving and cerebral protective effects. |
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