| 慢传输性便秘结肠神经系统的病理生理改变 |
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| 引用本文： | 王亚旭,刘宝华,张胜本. 慢传输性便秘结肠神经系统的病理生理改变[J]. 结直肠肛门外科, 2002, 8(1): 17-19 |
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| 作者姓名： | 王亚旭 刘宝华 张胜本 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所普外科,重庆,400042 |
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| 摘 要： | 目的：了解慢性输性便秘（STC）结肠壁神经系统的病理改变。方法：用免疫组化法检测了慢性输性便秘病人结肠肠壁神经元凋亡现象。结果：STC患者结肠壁神经元有凋亡现象发生，神经元内bcl-2含量下降，而bax无显著变化。结论：这种不恰当的细胞死亡－－病理性神经元凋亡可能在STC的发病过程中具有重要意义，提示通过抑制凋亡的发生是预防和治疗STC的一个有效途径。
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| 关 键 词： | 慢性传输性便秘 病理生理学 肠道动力 细胞凋亡 结肠神经系统 |
| 修稿时间： | 2001-06-28 |
PATHOPHYSIOLOGIC CHANGS OF COLONIC NERVE SYSTEM IN SLOW TRANSIT CONSTIPATION |
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| Wang Yaxu,Liu Baohua,Zhang Shengben. General Surgery Department,Daping Hospital,the Third Military medical Univercity,,China. PATHOPHYSIOLOGIC CHANGS OF COLONIC NERVE SYSTEM IN SLOW TRANSIT CONSTIPATION[J]. Journal of Colorectal & Anal Surgery, 2002, 8(1): 17-19 |
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| Authors: | Wang Yaxu Liu Baohua Zhang Shengben. General Surgery Department Daping Hospital the Third Military medical Univercity China |
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| Affiliation: | Wang Yaxu,Liu Baohua,Zhang Shengben. General Surgery Department,Daping Hospital,the Third Military medical Univercity,400042,China |
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| Abstract: | Objective:To study further about the mechanism and pathophysiology of STC.Methods: Apoptosis in neurons of colon were studied imunohistochemicaly.Results: In STC,there is apoptosis phenomenen,the content of bcl-2 is reduced sigificantly and the change of Bax is not significant in colonic neurons compared to control group.Conclusion: This kind of pathologic neuron apotosis is very important in STC mechanism.It indicated that inhibiting apoptosis in neurons may be an effective mathod for preventing and treating STC. |
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| Keywords: | Slow transit constipation Pathophysiology Instestinal motility Apoptosis |
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