幽门螺杆菌与非甾体消炎药相关消化性溃疡的临床研究——附69例报告

目的： 研究幽门螺杆菌（Ｈｐ） 根除对长期服用非甾体消炎药（ＮＳＡＩＤ） 的消化性溃疡愈合和复发的影响。方法：将６９ 例长期服用ＮＳＡＩＤ的消化性溃疡患者分为Ｈｐ 阳性雷尼替丁组２５ 例，Ｈｐ 阳性雷尼替丁加阿莫西林组２３ 例， Ｈｐ 阴性雷尼替丁组２１例， 三组的用药时间均为６周。结果： 三组溃疡愈合率依次为６４％ 、７４％ 、７１％（Ｐ＞ ０．０５）。追踪溃疡愈合者４３ 例， 并分为Ｈｐ 根除组１３ 例， Ｈｐ 持续阳性组１６ 例， Ｈｐ 持续阴性组１４ 例。均停用抗溃疡药物， 继续服用ＮＳＡＩＤ６ 个月后复查。累计溃疡复发率三组分别为３１％ 、４４％ 、２９％ （Ｐ＞ ０．０５）。结论： 根除Ｈｐ 不能提高ＮＳＡＩＤ相关消化性溃疡的愈合率， 亦不能降低其复发率， 且Ｈｐ 持续阳性者其溃疡复发率有升高趋势

Influence of Helicobacter pylori on healing and recurrence of peptic ulcer being correlated with nonsteroial antiinflammatory drug: report of 69 cases

Objective: To study influence of eradicating Helicobacter pylori (Hp) on healing and recurrence of peptic ulcer cases with long term nonsteroial antiinflammatory drug(NSAID) use Methods:69 peptic ulcer cases taking long term NSAID were divided into ranitidine group of Hp positive reaction( n =25, ranitidine 0 15 g,two times a day), ranitidine plus amoxicillin group of Hp positive reaction ( n =23,ranitidine 0 15 g,two times a day; amoxicillin 0 5 g,three times a day) and ranitidine group of Hp negative reaction ( n =21, Ranitidine 0 15 g,two times a day) Results:Ulcer healing rates in three groups were 64%,74%,71% in turn( P >0 05) 43 healed cases were divided into the eradicated Hp group( n =13),Hp lasting positive reaction group( n =16) and Hp lasting negative reaction group( n =14) Peptic ulcer drug use weren't stopped NSAID was taken continuously 43 cases were checked in 6 months U1cer recurrence rates in three healed groups were 31%,44%,29% respectively ( P >0 05) Conclusions: Eradicating Hp cannot improve the ulcer healing rates and cannot reduce the recurrence rates either But the ulcer recurrence rates of Hp lasting position reaction show a tendency to increase