| TRP超家族与肾脏 |
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| 引用本文： | 朱斌,陈楠.TRP超家族与肾脏[J].国际病理科学与临床杂志,2007,27(2):21-184. |
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| 作者姓名： | 朱斌 陈楠 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院肾脏科,上海,200025 |
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| 摘 要： | TRP(Transient receptor potentical)家族是非选择性阳离子通道家族，近来发现其与肾脏关系密切，如调节肾小管离子转运，肾脏微循环等。TRP通道异常可导致遗传性局灶节段硬化性肾病（FSGS），常染色体显性遗传多囊肾(ADPKD)，低镁血症继发低钙血症(HSH)等，对TRP通道的进一步研究将有助于临床肾脏病的防治。
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| 关 键 词： | 离子通道 TRP通道 肾疾病 |
| 文章编号： | 1673-2588(2007)02-0179-06 |
| 收稿时间： | 2006-7-17 |
| 修稿时间： | 2006年7月17日 |
TRP super family and kidney |
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| ZHU Bin,CHEN Nan.TRP super family and kidney[J].Journal of International Pathology and Clinical Medicine,2007,27(2):21-184. |
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| Authors: | ZHU Bin CHEN Nan |
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| Institution: | Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China |
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| Abstract: | TRP channels(Transient receptor potentical) including several subfamilies are nonselective cation channels.Recently they were found to be associated with kidney physiological regulation such as adjusting ionic transport in renal tubule and renal microcirculation.The abnormality of TRP channels can lead to some renal diseases such as familial FSGS,ADPKD,and HSH.Further researches on TRP channels would benefit the therapy and preclude of renal disease. |
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| Keywords: | cation channels TRP channels renal disease |
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