| 醋酸地塞米松双层缓释贴膜的生物安全性评价 |
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| 引用本文： | 刘国勤,马晓蓬,宋培智,刘海英,侯惠民,贺芬.醋酸地塞米松双层缓释贴膜的生物安全性评价[J].第二军医大学学报,2002,23(6):665-666. |
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| 作者姓名： | 刘国勤 马晓蓬 宋培智 刘海英 侯惠民 贺芬 |
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| 作者单位： | 1. 解放军第411医院海军口腔专科中心,上海,200081
2. 上海医药工业研究院 |
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| 摘 要： | 目的：评价醋酸地塞米松双层缓释贴膜的生物安全性，方法：采用该贴膜分别进行细胞毒性实验，溶血实验、急性毒性实验（小鼠）和口腔粘膜刺激实验（新西兰白兔），结果：该贴膜无明显的细胞毒性作用；急性毒性实验结果无毒，溶血率为0．46％，口腔粘膜刺激实验结果，实验且与阴性对照组无显著性差异，结论：醋酸地塞米松双层贴膜具有良好的生物安全性。
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| 关 键 词： | 醋酸地塞米松 双层缓释贴膜 生物安全性 毒性 |
| 文章编号： | 0258-879X(2002)06-0665-02 |
| 修稿时间： | 2002年3月1日 |
Biological assessment of sustained-release bistratal drug-film of dexamethasoni acetate |
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| LIU Guo Qin ,MA Xiao Peng ,SONG Pei Zhi ,LIU Hai Ying ,HOU Hui Min ,HE Fen.Biological assessment of sustained-release bistratal drug-film of dexamethasoni acetate[J].Academic Journal of Second Military Medical University,2002,23(6):665-666. |
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| Authors: | LIU Guo Qin MA Xiao Peng SONG Pei Zhi LIU Hai Ying HOU Hui Min HE Fen |
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| Institution: | LIU Guo Qin 1,MA Xiao Peng 1,SONG Pei Zhi 1,LIU Hai Ying 1,HOU Hui Min 2,HE Fen 2 |
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| Abstract: | Objective:To evaluate the biological safety of the sustained release bistratal drug film of dexamethasoni acetate (DA). Methods:A series of tests, including acute toxicity test, cytotoxity test (agar overlay), oral mucous membrane irritation test and haemolysis test were conducted. Results:Cytotoxic effect was not observed, nor was toxic effect in mouse toxicity test. The haemolysis rate of this material was 0.46%. Local mucous membrane irritation reaction was not found. Conclusion:The drug film of DA shows excellent biocompatibility on the preliminary tests. |
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| Keywords: | dexamethasone delayed action preparations drug film biological safety toxicity |
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