Residual effects of prolonged cannabis administration on exploration and DRL performance in rats |
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Authors: | Alexander Stiglick Harold Kalant |
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Institution: | (1) Department of Pharmacology, University of Toronto, M5S 2S1 Toronto, Canada;(2) Addiction Research Foundation of Ontario, M5S 2S1 Toronto, Canada |
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Abstract: | Chronic oral administration of cannabis extract to rats (daily
9 dose 20 mg/kg) was examined for its residual effect on open field activity and DRL (differential reinforcement of low-rate responding) performance, following a 2–3-month drug-free period. Locomotor activity during the latter part of an open field test was markedly increased in rats previously treated for either 6 months or 3 months with the drug. The same treatments also produced a significant impairment on a DRL-20 task relative to control subjects' performance. These and other findings (impaired maze learning and facilitated two-way shuttle box avoidance) might mean that cannabis produces long-lasting hippocampal, dysfunction in rats. |
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Keywords: | Chronic cannabis Locomotor activity DRL performance Rat |
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