Chemoradiotherapy for advanced head and neck cancer — Analysis of a prospective, randomized trial |
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Authors: | D Mitra S Basu A R Deb M A Rashid and P K Sur |
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Institution: | (1) Department of Radiotherapy, N.R.S. Medical College, Kolkata;(2) Department of E.N.T, North Bengal Medical College, India;(3) IPGMER, Kolkata;(4) Department of Radiotherapy, IPGMER, Kolkata |
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Abstract: | Objective: To study the efficacy of neo-adjuvant chemotherapy followed by radiotherapy in advanced head and neck cancer.Study design: Randomised, prospective study.Setting: Tertiary academic referral center.Patients: One hundred and eighty patients of advanced head and neck squamous cell carcinoma.Intervention: Patients were randomized into two arms. The study arm (CT-RT arm) received 3 cycles of anterior chemotherapy with Inj. Cisplatin
100 mg/m2 on D1 and Inj 5F.U. 700 mg/m2 on D1-D4 at an interval of 21 days, followed by external radiation. The control arm (RT arm) received external radiotherapy only.
The dose of Radiotherapy was 64 to 68 Gy in conventional fractionation.Results: Patients of CT-RT showed better tumour control locally than patients who received only RT. Toxicities were commoner in CT-RT
arm but they were manageable. 5 year survival is higher in the CT-RT arm (21% vs 16%; p value> 0.05).Conclusion: Anterior chemotherapy with Cisplatin and 5F.U. is associated with good clinical response which is translated into increased
survival along with acceptable toxicities. |
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Keywords: | Head & Neck Cancer Neo-adjuvant Chemotherapy Cisplatin and 5F U |
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