首页 | 本学科首页   官方微博 | 高级检索  
检索        

非小细胞肺癌端粒酶活力表达及其临床意义
引用本文:陈琼,易红,等.非小细胞肺癌端粒酶活力表达及其临床意义[J].湖南医科大学学报,2001,26(3):221-222.
作者姓名:陈琼  易红
作者单位:[1]中南大学湘雅医院呼吸内科,长沙410008 [2]南大学湘雅医院中心实验室,长沙410008
摘    要:目的:探讨非小细胞肺癌组织端粒酶活性表达及其临床意义。方法:应用TRAP-PCR-ELISA方法检测36例非小细胞肺癌组织及相应的32例癌旁组织,9例肺良性病变组织和9例正常肺组织中端粒酶活性表达。结果:肺癌组织中端粒酶活性表达阳性率为75%(27/36),癌旁组织为6.25%(2/32),肺良性病变组织为11.1% (1/9),正常肺组织为0%(0/9)。肺癌组织端粒酶活性表达与肺癌病理类型、组织分化程度、原发性肿瘤大小、淋巴结转移情况及临床分期无明显相关。结论:端粒酶在肺癌组织中的高表达可作为肺癌诊断和鉴别诊断的重要分子生物学指标之一。

关 键 词:肺肿瘤  端粒酶  诊断  非小细胞肺癌

Study on telomerase activity and its clinical value in human non small cell lung cancer]
Q Chen,J He,H Yi.Study on telomerase activity and its clinical value in human non small cell lung cancer][J].Bulletin of Hunan Medical University,2001,26(3):221-222.
Authors:Q Chen  J He  H Yi
Institution:Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Abstract:OBJECTIVE: To investigate telomerase activity and its clinical value in human non small cell lung cancer. METHODS: Using the method of TRAP-PCR-ELISA, we measured telomerase activity in human non small cell lung cancerous, adjacent, lung benign lesion, and normal lung tissues. RESULTS: The positive rate of telomerase activity was 75%(27/36) in lung cancerous tissues; 6.25%(2/32) in adjacent tissues; 11.1%(1/9) in lung benign lesion tissues; and 0%(0/9) in normal lung tissues. There was no significant difference in telomerase activity among the pathological type, the degree of tissue differentiation, the size of tumor, lymph node metastasis, and clinical stage in the patients with lung cancer. CONCLUSION: The telomerase activity may become an important molecular marker in the diagnosis and differential diagnosis of human non small cell lung cancer.
Keywords:
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号