Depression of afferent-induced primary afferent depolarization at the lumbar spinal cord following concussive head injury |
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| Authors: | Y Katayama DP Becker RL Hayes |
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| Institution: | 1. University Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland;2. Department of Internal Medicine and Cardiology, Sohag University, Egypt;3. Mohamed Bin Khalifa Cardiac Centre, Bahrain;4. Division of Cardiology, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy;5. Royal Brompton and Harefield Hospital Trust and Imperial College, National Heart and Lung Institute, London, United Kingdom;6. Centre for Molecular Cardiology, Zurich University, Switzerland |
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| Abstract: | Afferent-induced primary afferent depolarization (PAD) was depressed for 2-5 min following concussive head injury in the cat, as assessed by dorsal root potentials and augmentation of antidromic dorsal root potentials, both evoked by stimulation of adjacent dorsal roots. These changes in PAD were abolished by spinal cord transection but not affected by midpontine transection. Spontaneous dorsal root potentials, resting amplitudes of antidromic dorsal root potentials and reductions of antidromic dorsal root potentials following tetanic root stimulation were not substantially altered by injury. These findings suggest that concussive head injury depresses spinal interneuronal transmission by neurally mediated processes involving the bulbar brainstem. |
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| Keywords: | concussion head injury primary afferent depolarization segmental sensory function spinal reflex |
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