围手术期预防性应用抗菌药物系统干预效果分析

目的了解福建医科大学第一附属医院围手术期预防性应用抗菌药物的使用情况,对比分析系统干预对合理使用抗菌药物的作用。方法收集福建医科大学第一附属医院2010年系统干预前和2012年系统干预后治疗住院患者病历各224份,比较系统干预前后围手术期预防性应用抗菌药物的使用情况。结果干预后抗菌药物使用率(58.03%)、使用强度(40.97)、抗菌药物费用占药品费用比例(12.44%)住院费用比例(6.58%)、平均用药天数(2.32 d)均较干预前降低;Ⅰ类和Ⅱ类切口抗菌药物平均使用时间分别为(1.68±1.07)和(3.28±1.13)d,均低于干预前的(3.98±1.02)和(5.21±1.34)d,差异均有统计学意义(P=0.000)。结论系统干预对围手术期预防性应用抗菌药物具有积极的作用,但仍存在不合理用药现象。

Effect of systemic intervention on prophylactic use of antibacterials in perioperative period

ObjectiveTo examine prophylactic use of antibacterials in perioperative period in a hospital and to analyze the effect of systemic intervention on rational use of antibacterials.MethodsTotally 224 medical records in 2010 before the intervention and 224 in 2012 after the intervention were collected in a hospital and comparative analyses were made for the time pre-and post-intervention on antibacterials use in perioperative period.Results The rate of the prophylactic antibacterials,antibacterial use density,proportion of antibacterial drug cost for total of medicine cost and hospital cost,and the average days of antibacterials use after the intervention were lower than those before the intervention.The average time of application of antibacterials type Ⅰ and Ⅱ incisions was reduced,with a statistically significant difference(P<0.05).The rational prophylactic use of antibacterials in perioperative period was markedly improved.ConclusionSystemic intervention in a hospital results in positive effect on the prophylactic use of antibacterials in perioperative period,but there is still irrational drug use.