乙型肝炎疫苗小剂量皮内接种法的免疫效果观察

本文观察了乙型肝炎血源性疫苗在健康人群中进行不同剂量、不同接种途径的免疫效果。接种人数120人,为3~70岁农民,其中男性55人,女性65人。随机分成2组。试验结果:皮下组和皮内组在3针接种后的抗-HBs阳转率和抗-HBs浓度(P/N均值)分别为98.4%;98.3%;88.0对89.4;P>0.05;t<2。疫苗保护效果两组均为98.0%。表明皮内组可以获得与皮下组相似的免疫效果,能让更多人接受疫苗接种,得到保护,且减少接种者费用,具有重要的社会效益和经济效益。

Observation on Immunogenic Effct of Intradermal Inoculation of Small Dose of Hepatitis B Vaccine

The immunogenic effect of intradermal inoculation of small dose of HB vaccine was evaluated in 120 seronegative villagers (men: 55, women: 65) whose ages were from 3 to 70. These participants were randomly divided into subcutaneous group (I) and intradermal group (II). The results showed that the anti-HBs seroconversion rates and P/N ratios of those who showed the seroconversion for group I, II were 98.4%, 98.3% and 88.0, 89.4, respectively after the third injection. There was no significant difference between the groups in the seroconversion rates and their P/N ratios (P greater than 0.05). It is concluded that in these two groups small doses of HB vaccine have stimulated high immune responses. Intradermal small dose regimen is safe, more economic and will make the HB vaccine available to more people.