唑来膦酸合并放射治疗骨转移癌临床研究

目的:观察唑来膦酸联合放射治疗对骨转移癌疼痛的疗效及不良反应.方法:98例骨转移癌患者随机分成观察组(51例)和对照组(47例).观察组静滴唑来膦酸4 mg加局部放疗37.5GY/15F,之后再静滴唑来膦酸4 mg;对照组则单纯行放疗.结果:观察组与对照组止痛有效率分别为88.2%和74.5%(P＞0.05),多发骨转移癌疼痛病灶研究组与对照组止痛有效率分别为86.5%和67.6%(P＜0.05),随访2个月后观察组与对照组止痛有效率分别为86.3%和66.0%(P＜0.05).结论:唑来膦酸联合放射治疗骨转移癌疼痛疗效优于单纯放疗,唑来膦酸副作用轻.

CLINICAL STUDY OF METASTATIC BONE TUMOUR TREATED WITH ZOLEDRONIC ACID COMBINED WITH RADIOTHERAPY

Objective: To evaluate the efficacy of zoledronic acid combined with radiotherapy to relieve pain due to metastatic bone tumours.Methods: 98 patients with metastatic bone tumours were randomly divided into observation group(51 cases) and control group(47 cases).Observation group was treated with zoledronic acid(4 mg,i.v.) and combined with radiotherapy(DT 37.5GY/15F);control group was only treated by radiotherapy.Results: The effective rate of the observation group and control group was 88.2% and 74.5%,respectively(P>0.05).For multiple focus of bone metastasis tumour pain,the effective rate of observation group was 86.5%,while the control group was 67.6%(P<0.05);after two-month follow-up,the effective rate of the observation group and control group was 86.3% and 66.0%,respectively(P<0.05).Conclusion: Acid combined with radiotherapy is effective to relieve pain from metastatic bone tumours,and the side effect was mild.