| 罗格列酮联合二甲双胍对2型糖尿病肾病危险因素的影响 |
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| 引用本文： | 吴刚,范小云,李襄君. 罗格列酮联合二甲双胍对2型糖尿病肾病危险因素的影响[J]. 四川医学, 2010, 31(5): 629-630 |
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| 作者姓名： | 吴刚 范小云 李襄君 |
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| 作者单位： | 重庆市第六人民医院内科,重庆,400060;重庆市第六人民医院内科,重庆,400060;重庆市第六人民医院内科,重庆,400060 |
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| 摘 要： | 目的探讨罗格列酮和二甲双胍联用对2型糖尿病肾病危险因素的干预效果。方法选取2007年11月~2009年9月本院收治2型糖尿病患者96例,采用罗格列酮联合二甲双胍治疗,进行为期12周的用药观察。结果治疗12周后,96例糖尿病患者FPG、2h PG及HbA1c均明显下降（P〈0.01）,FINS及IR也均较治疗前明显降低（P〈0.01）;治疗后TC、TG、SBP、DBP均明显下降（P〈0.01）,HDL-C较治疗前升高,但差异无统计学意义（P〉0.05）;治疗后LDL-C、BMI、WC均较治疗前有降低趋势,但无统计学意义（P〉0.05）;治疗后UAER和24 h尿白蛋白明显降低（P〈0.01）,Cr、BUN较治疗前下降,但无统计学意义（P〉0.05）。结论罗格列酮联合二甲双胍应用可显著改善2型糖尿病肾病发生的危险因素。
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| 关 键 词： | 糖尿病肾病 危险因素 罗格列酮 二甲双胍 |
The effects of rosiglitazone combined with metformin on risk factors of diabetic nephropathy in type 2 diabetic patient |
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| WU Gang,FAN Xiao-yun,LI Xiang-jun. The effects of rosiglitazone combined with metformin on risk factors of diabetic nephropathy in type 2 diabetic patient[J]. Sichuan Medical Journal, 2010, 31(5): 629-630 |
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| Authors: | WU Gang FAN Xiao-yun LI Xiang-jun |
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| Affiliation: | .The Sixth People′s Hospital of Chongqing,Chongqing 400060,China |
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| Abstract: | Objective To observe the effects of rosiglitazone combined with metformin on risk factors of diabetic nephropathy in type 2 diabetic patient.Methods 96 type 2 diabetes patients from 2007 to 2009 were treated with hypoglycemle agent plus rosiglitazone and metformin over a course of 16 weeks.Results After treatment,FPG,2h PG,HbA1c,FINS,IR,TC,TG,SBP and DBP in 96 type 2 diabetic patients decreased obviously(P<0.01).The level of HDL-C increased,but there was no significant difference(P>0.05).UAER and albumen in... |
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| Keywords: | diabetic nephropathy risk factors rosiglitazone metformin |
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