| 冠心病患者血浆P选择素水平分析及其与预后的相关性研究 |
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| 引用本文： | 王志军,柯元南,周建芝.冠心病患者血浆P选择素水平分析及其与预后的相关性研究[J].山东医药,2010,50(4):38-40. |
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| 作者姓名： | 王志军 柯元南 周建芝 |
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| 作者单位： | 1. 华北煤炭医学院附属医院,河北唐山,063000
2. 卫生部中日友好医院 |
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| 摘 要： | 目的观察冠心病患者血浆P选择素（P—Selectin）水平变化，评价冠心病患者P—Selectin水平的影响因素及其与患者预后的关系。方法冠心病患者应用酶联免疫法测定血浆中P—Selectin水平，记录心血管疾病危险因素、伴随临床疾病、超声心动图、冠状动脉造影结果及介入治疗措施等，记录随访1a时心血管病事件。结果冠心病患者P—Selectin水平高于对照组，P—Selectin水平与冠心病严重程度、高敏C反应蛋白（hsCRP）、肌酸肌酶同工酶（CK—MB）、血胆固醇（CHO）水平及严重病变支数相关。临床合并糖尿病和介入治疗术后的冠心病患者P—Selectin较高。患者住院时P-Selectin水平增高与随访1a发生心血管病事件相关。结论冠心病患者P—Selectin水平升高能够反映病情的严重性，而且预示患者1a内发生心血管事件的危险性增加。
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| 关 键 词： | 冠心病 P选择素 预后 相关性研究 |
Correlative study of P-Selectin and prognosis in coronary heart disease patients |
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| WANG Zhi-jun,KE Yuan-nan,ZHOU Jian-zhi.Correlative study of P-Selectin and prognosis in coronary heart disease patients[J].Shandong Medical Journal,2010,50(4):38-40. |
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| Authors: | WANG Zhi-jun KE Yuan-nan ZHOU Jian-zhi |
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| Institution: | WANG Zhi-jun1,KE Yuan-nan,ZHOU Jian-zhi(1 Affiliated Hospital of North China Coal Medical College,Tangshan 063000,P.R.China) |
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| Abstract: | Objective To evaluate the relationship between P-Selectin level and prognostic in coronary heart disease(CHD) patients.Methods A total of 203 consecutive hospitalized CHD patients were enrolled.Euzymelinked immunosorbent assay was used to detect the level of P-Selectin.Risk factors of cardiovascular disorders,ultrasonic echocardiogram,coronary arteriography results and interventional therapy results were recorded as well as one-year follow-up recurrent cardiovascular events.Results The P-Selectin level of C... |
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| Keywords: | coronary heart disease P-Selectin prognosis correlative study |
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