基质金属蛋白酶组织抑制因子-1在大肠癌中的表达

目的 探讨基质金属蛋白酶组织抑制因子-1（TIMP-1）在大肠癌中的表达及临床意义。方法 采用免疫组化S-P法对54例大肠癌组织的TIMP-1进行检测，结合临床资料进行分析。结果 TIMP-1主要表达于大肠上皮细胞膜和细胞浆，正常大肠组织表达率为100％，在大肠癌组织的表达率为59．6％（31／52），且淋巴结转移大肠癌组表达低于无淋巴结转移组（P〈0．05）。结论 TIMP-1的表达程度与大肠癌淋巴结转移呈负相关，TIMP-1的表达程度降低在大肠癌病程演进中可能发挥一定的作用。

Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications

Objective To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1(TIMP-1)in colorectal carcinoma.Methods TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method,and the results were analyzed in relation to the clinical data of patients.Results TIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells,and its expression rate was 100% in normal tissue but only 59.6%(31/52)in colorectal carcinoma tissues.In addition,the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis(P<0.05).Conclusion The expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma,and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma.