| 口腔鳞癌中VEGF和MMP-2的表达及其相关性 |
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| 引用本文： | 王岩,陈卫民,孙国洪.口腔鳞癌中VEGF和MMP-2的表达及其相关性[J].临床口腔医学杂志,2006,22(12):707-709. |
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| 作者姓名： | 王岩 陈卫民 孙国洪 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院口腔医学中心,湖北,武汉,430030 |
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| 摘 要： | 目的：探讨MMP-2、VEGF在口腔鳞状细胞癌（OSCC）中的表达、两者相关性及其作用。方法：采用免疫组化法检测MMP-2和VEGF在86例OSCC和20例正常非肿瘤组织中的表达情况及两者的相关性。结果：MMP-2和VEGF在OSCC中的阳性表达率分别为85．9％和88．4％，均高于正常组织的10．0％，15．0％；差异均有显著性差异如〈0．01）：MMP-2和VEGF在OSCC中的表达呈正相关（CAMMA值0．476，p=0．007）。结论：MMP-2和VEGF在OSCC中呈过表达，二者之间的相互作用与OSCC增殖、侵袭和转移密切相关。
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| 关 键 词： | 血管内皮生长因子 基质金属蛋白酶 口腔鳞状细胞癌 |
| 文章编号： | 1003-1634（2006）12-0707-03 |
| 收稿时间： | 2006-11-13 |
| 修稿时间： | 2006-11-13 |
Expression of vascular endothelial growth factor (VEGF) and matrix matalloproteinases-2 (MMP-2) in oral squamous cell carcinoma and their correlation |
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| WANG Yan,CHEN Wei-min,SUN Guo-hong.Expression of vascular endothelial growth factor (VEGF) and matrix matalloproteinases-2 (MMP-2) in oral squamous cell carcinoma and their correlation[J].Journal of Clinical Stomatology,2006,22(12):707-709. |
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| Authors: | WANG Yan CHEN Wei-min SUN Guo-hong |
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| Institution: | Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
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| Abstract: | Objective:To study the protein expression of vascular endothelial growth factor(VEGF)and matrix matalloproteinases-2 (MMP-2)in oral squamous cell carcinoma(OSCC)and their correlation,and the implication .Method:Tissue sections from 86 OSCC patients were examined using immunohistochemistry technique for protein expression of MMP-2 and VEGF. Result: Positive MMP-2 and VEGF immunostaining were detected in 85.9% and 88.4% of OSCC respectively.Expression of MMP-2 have a significant positive relation toVEGF. Conclusion:VEGF and MMP-2 have a significant positive correlation in OSCC. MMP-2 plays a important role in VEGF development. Over-expression of MMP-2 and VEGF contributed to tumor cell proliferation,development and metastases. |
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| Keywords: | vascular endothelial growth factor(VEGF) matrix matalloproteinases-2 (MMP-2) oral squamous cell carcinomas (OSCC) |
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