腔内交替注药治疗恶性胸腔积液46例分析

目的 探讨腔内交替注药治疗恶性胸腔积液的临床效果。方法 回顾性分析恶性胸腔积液46例的治疗，腔内交替注入两组抗癌药物的临床资料。结果 全组病例治疗总有效率84.8％，存活5个月以上24例，其中1年以上5例，最长存活64个月。结论 尽量一次性抽尽胸液，能提高药物的胸内浓度，增强药物效果。两组抗癌药物交替腔内注射能够起协同作用，减少单种药物在胸内的积蓄，适合于反复抽液注药患者的长期治疗。

Alternately intrapleural injections for the treatment of malignant hydrothorax:an analysis of 46 cases

Objective To investigate the effectiveness of alternately intrapleural injections of drugs on maligant hydrothorax.Methods A retrospective analysis was carried out using the clinical data of 46 patients of malignant hydrothorax treated with alternately intrapleural injections after evacuation of pleural fluid at one aspiration.Results The overal effective rate was 84.8%.The survival time was more than 5 months in 24 patients,and more than 12 months in 5 patients.The longest was 64 months.Conclusion Evacuation of the pleural fluid at one aspiration can increase the concentrations in the pleural carity and strengthen the effectiveness of drugs.Alternate applications of two groups of anticarcinogons can act in synergy and reduce the acumulation of single drugs,and are suitable for patients needing long-term repeated aspirations and injections.