STK15基因在神经胶质瘤中的表达

目的探讨丝氨酸/苏氨酸激酶15(serine/threoninekinase15,STK15)在神经胶质瘤组织中的表达及其与胶质瘤临床病理分级的关系。方法采用免疫组化SP法检测STK15在62例手术切除的胶质瘤组织及8例正常脑组织标本中的表达,并分析STK15在胶质瘤中的表达与胶质瘤病理分级的关系。结果STK15在胶质瘤组织中的阳性表达率为46.77%(29/62),在正常脑组织中表达率为0%(0/8),两者相较,相差显著(P<0.05);STK15基因的表达与胶质瘤病理分级呈显著正相关(P<0.05),与病人年龄、性别及肿瘤大小无关。结论STK15基因可能在胶质瘤发生发展中起作用,提示其过表达程度可作为判定胶质瘤恶性程度新的指标。

Expression of STK15 Gene in Gliomas and Its Meaning

Objectives To explore the expression of serine/threonine kinase15(STK15)in gliomas and its relationship with the pathological grades of gliomas.Methods The expression of STK15 gene was determined by immunohistochemistry method in 62 cases of gliomas and 8 cases of normal brain tissues.The relationship between STK15 expression level in gliomas and pathological grade was analyzed.Results The positive rate of STK15 expression was 46.77%(29/62)in the gliomas.There was no expression of STK15 in all the normal brain tissues.There was significant difference in the positive expression rate of STK15 between the gliomas and normal brain tissues(P<0.05).STK15 expression level was positively related to pathological grades of gliomas,but not to patients' age and sex,and size of the tumors.Conclusions STK15 may play a role in the pathogenesis and development of glioma.It is suggested that the overexpression of STK 15 may be a marker of malignant glioma.