D-二聚体与纤维蛋白（原）降解产物在冠心病诊断中的应用价值

目的探讨D-二聚体（D-D）与纤维蛋白（原）降解产物（FDP）的检测结果在冠心病（CHD）患者中的临床应用价值。方法对52例急性心肌梗死（AMI）患者、48例不稳定性心绞痛（UAP）患者、42例稳定性心绞痛（SAP）患者,采用ACL900全自动血凝仪,通过胶体免疫比浊法定量检测血浆中D—二聚体与纤维蛋白（原）降解产物的含量,并与40例正常对照者进行对照,探讨其临床应用价值。结果血浆D-D和FDP含量及阳性检出率,AMI组比UAP组、SAP组和正常对照组明显升高,差异有统计学意义（P〈0.01）;UAP组比SAP组和正常对照组明显升高,差异也有统计学意义（P〈0.01）;SAP组比正常对照组略有升高,但差异无统计学意义（P〉0.05）。结论血浆中D-D和FDP的含量可作为AMI的诊断指标及UAP和SAP的鉴别诊断指标,D-D和FDP联合检测更有助于提高冠心病的诊断。

The application value of D-dimer and fiber protein degradation products in diagnosis of coronary heart disease

Objective To study the clinical application value of D-dimer(D-D) and fiber protein(former) degradation products(FDP) in the coronary heart disease(CHD).Methods D-D and FDP were tested by immunonephelometry in AMI,UAP and SAP.The results were analyzed by statistics.Results The levels of D-D and FDP of group AMI are higher than its of UAP,SAP and normal group,as well as there are significant difference(P<0.01).The levels of D-D and FDP of group UAP are higher than its of SAP and normal group,as well as there are significant difference(P<0.01).The levels of D-D and FDP of group SAP are higher than its of normal group,however,there are no significant difference(P>0.05).Conclusion D-D and FDP can be used in the diagnosis of coronary heart disease,and they can help diagnosis of coronary heart disease.