| 慢性胃病和胃癌患者脂质过氧化的研究 |
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| 引用本文： | 曹曼林 徐采朴. 慢性胃病和胃癌患者脂质过氧化的研究[J]. 现代诊断与治疗, 1993, 4(3): 231-233 |
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| 作者姓名： | 曹曼林 徐采朴 |
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| 作者单位： | 兰州军区总医院理疗科(曹曼林)，第三军医大学西南医院(徐采朴)，第三军医大学西南医院(高锋) |
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| 摘 要： | 采用改良硫代巴比妥酸法测定脂质过氧化反应(Lipid peroxidation, LPO)的分解产物丙二醛(Malonaldehyde, MDA),观察了96例慢性胃病和40例胃癌患者血浆和病变组织中MDA的含量。结果发现,胃溃疡和胃癌患者的血浆和组织中MDA含量均显著高于健康对照血浆(P<0.05和0.01)及浅表性胃炎粘膜组织(P<0.01和0.001)。慢性胃炎组和对照组之间没有明显差别(P>0.05)。癌旁组织中MDA含量高于慢性胃炎(P<0.01)。但与胃溃疡之间没有差别(P>0.05)。提示,自由基与良性慢性胃粘膜损伤没有明显关系,但可能参与胃粘膜从良性向恶性演变的过程,在胃癌的发生中起重要的作用。
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| 关 键 词： | 脂质过氧化 胃病 胃癌 自由基 |
A Study of Lipid Peroxidation in Patients with Chronic Gastric Diseases and Gastric Cancer |
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| Cao Manlin,et al.. A Study of Lipid Peroxidation in Patients with Chronic Gastric Diseases and Gastric Cancer[J]. Modern Diagnosis & Treatment, 1993, 4(3): 231-233 |
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| Authors: | Cao Manlin et al. |
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| Affiliation: | General Hospital of Lanzhou Military |
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| Abstract: | Plasma and gastric mucosa concentrations of malonaldehyde(MDA), production of lipid peroxidation were assayed in 96 patients with chronic gastric diseases and 40 patients with gastric cancer. MDA was greatly increased in gastric ulcer and gastric cancer (P<0.05～0.001), and no difference was found between chronic superficial gastritis, chronic atrophic gastritis and healthy controls(P>0.05). MDA level in gastric mucosa adjacent to cancer was also higher than benign mucosa(P<0.01). The results suggested that free radicals have no correlation with chronic gastric diseases, but may play a role in the process of benign mucosa becoming malignant, and it may be involved in gastric cancer. |
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| Keywords: | Lipid peroxidation Gastric disease Gastric cancer Free radical |
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