蛛网膜下隙出血后脑动脉痉挛形态学研究

采用大鼠蛛网膜下隙出血模型，经光镜和Ｖｉｄａｓ图像分析的方法，对不同时间段的脑动脉平滑肌的横断面积（Ｓ１），内膜的横断面积（Ｓ２），脑动脉壁横断面积（Ｓ３），脑动脉腔横断面积（Ｓ４），Ｖ１，平滑肌的体密度（Ｓ１／Ｓ３）；Ｖ２；内的体密度（Ｓ２／Ｓ３）；Ｄ１；蛛网膜下隙面脑动脉壁厚度；Ｄ２：脑面及动脉壁厚度进行了观察测定发现蛛网膜下隙出血后脑血管痉挛具有双相性，管腔缩窄，管壁增厚，急性脑血管痉挛比迟

MORPHOLOGICAL STUDY ON CEREBRAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE

A rat subarachnoid hemorrhage (SAH) model was set up in this study. The cross-sectional areas of the smooth muscles, the intima, the vessel wall and the luminal, the volume densities of the smooth muscles and the intima, the radial thickness of the vessel wall on the brain surface and the subarachnoid space were measured with light microscopy and image analysis system. A biphasic vasospasm was found in the cerebral vasospasm (CVS) after SAH. The range of narrowing the vessel lumen and the wall thickness were more obvious in the acute phase than that in the delayed phase. The wall thickness of the subarachnoid aspect increased significantly than that of the brain aspect. The changes of the middle cerebral arteries were even more distinct than those in the basilar arteries. The volume density of the individual components of the basilar and the middle cerebral arterial wall didn't change in the various periods following SAH. The results suggest that the structural changes in the cerebral vasospasm of SAH do not directly contribute to the increase in the components of the wall.