| 蝙蝠葛酚性碱对大鼠的行为致畸性 |
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| 引用本文： | 王光祖 蒋芸. 蝙蝠葛酚性碱对大鼠的行为致畸性[J]. 中国药理学与毒理学杂志, 1992, 6(2): 157-158 |
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| 作者姓名： | 王光祖 蒋芸 |
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| 作者单位： | 同济医科大学工业毒理研究室，同济医科大学工业毒理研究室，同济医科大学临床药理研究室 湖北省卫生职工医学院卫生管理系，沙市 434000，武汉 430030 |
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| 摘 要： | <正> 蝙蝠葛酚性碱(phenolic alkaloid of Menispermum dauricum,PAMD)系从蝙蝠葛(Menispermum dauricum DC)中提出的酚性生物碱,药理试验表明有较好的抗心律失常作用,本实验研究曾发现,PAMD对大鼠母体无毒性作用,亦无致畸胎作用,但40mg·kg~(-1)染毒,可引起胎鼠胸骨,蝶骨和枕骨发育迟缓.本文进一步观察其对仔鼠早期行为发育的影响.
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| 关 键 词： | 蝙蝠葛酚性碱 大鼠 致畸性 |
Behavioral teratogenicity of phenolic alkaloid of Menispermum dauricum in rats |
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| WANG Guang-Zu,JIANG Yun,HU Chong-JiaDepartments of Industrial Toxicology and Clinical Pharmacology,Tongji Medical University,Wuhan. Behavioral teratogenicity of phenolic alkaloid of Menispermum dauricum in rats[J]. Chinese Journal of Pharmacology and Toxicology, 1992, 6(2): 157-158 |
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| Authors: | WANG Guang-Zu JIANG Yun HU Chong-JiaDepartments of Industrial Toxicology Clinical Pharmacology Tongji Medical University Wuhan |
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| Affiliation: | WANG Guang-Zu,JIANG Yun,HU Chong-JiaDepartments of Industrial Toxicology and Clinical Pharmacology,Tongji Medical University,Wuhan 430030 |
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| Abstract: | Pregnant rats were given phenolic alkaloid of Menispermum dauricum at different concentrations. A set of behavioral tests were performed to observe the effects on the development and the behavioral function of the offspring. After prenatal exposure to the drug in a dose of 80 mg·kg-1 or above, paps body weight gain decreased, time of the negative earth-tendency test prolonged and the times of excre-tion and making up in the open-field test increased compared with those of the control. No effect was found with the lower dosage. It is therefore suggested that the drug has some effects on the development and behavior of the offspring. |
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| Keywords: | phenolic alkaloid of Menispermum dauricum rat teratogenicity |
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