多索茶碱与氨茶碱在治疗慢性阻塞性肺病中的疗效观察

目的探讨多索茶碱与氨茶碱治疗慢性阻塞性肺疾病的临床效果。方法收集2010年3月至2011年3月在我院治疗的76例慢性阻塞性肺病患者,随机分为治疗组和对照组各38例,治疗组在常规治疗的基础上给予多索茶碱,对照组给予氨茶碱,观察记录两组患者的临床症状改善、肺功能、血气分析和不良反应。结果治疗组总有效率为92.11%,对照组总有效率为81.58%,治疗组总有效率高于对照组,两组比较差异有统计学意义(P<0.05);治疗组肺功能和血气分析指标变化均优于对照组,两组比较差异有统计学意义(P<0.05);两组患者不良反应发生率比较差异有统计学意义(P<0.05)。结论多索茶碱治疗慢性阻塞性肺疾病较氨茶碱安全、有效,可作为慢性阻塞性肺疾病治疗方案的首选。

Clinical Efficacy of Doxofylline and Aminophylline in Treatment of Chronic Obstructive Pulmonary Disease

Objective To discuss the clinical therapeutic effect of doxofylline and aminophylline in treatment of chronic obstructive pulmonary disease(COPD).Methods 76 patients with COPD accepted by our hospital from March 2010 to March 2011 were collected and randomly divided into two groups,the treatment group and the control group,38 cases in each group.The patients in the treatment group were treated by doxofylline on the basis of conventional drugs.The patients in the control group were treated by aminophylline on the basis of conventional drugs.Clinical symptoms improvement,pulmonary function,blood gas analysis and adverse reaction of two the groups were observed and recorded.Results After treatment,the total effective rate in the treatment group was 92.11%,and in the control group was 81.58%,which was significantly lower than the treatment group(P<0.05).The pulmonary function and blood gas analysis in the treatment group was higher than control group(P<0.05).There was significant difference of adverse reaction between the two groups(P<0.05).Conclusion Doxofylline is more safe and effective than aminophylline in treatment of COPD,which can be the first treatment choice.