| 体外循环期间肺动脉持续氧合血灌注对肺功能及细胞间黏附分子-1表达的影响 |
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| 引用本文： | 袁峰,李晓峰,赵宇东,武文琦,柏松,高国庆,李仲智.体外循环期间肺动脉持续氧合血灌注对肺功能及细胞间黏附分子-1表达的影响[J].中国循环杂志,2008,23(3):221-224. |
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| 作者姓名： | 袁峰 李晓峰 赵宇东 武文琦 柏松 高国庆 李仲智 |
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| 作者单位： | 1. 首都医科大学附属北京儿童医院,心脏中心,北京市,100045
2. 北京市,首都医科大学医学实验与测度中心 |
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| 摘 要： | 目的:探讨体外循环(CPB)期间肺动脉持续氧合血灌注对肺功能及肺组织内细胞间黏附分子-1(ICAM-1)表达的影响。方法:实验用健康小型猪随机分为两组,对照组常规行CPB,实验组行CPB期间肺动脉持续灌注氧合血。分别于不同时间点留取肺组织和血液标本,进行肺功能和肺含水率的测定以及肺组织的病理学观察,并采用逆转录聚合酶链反应(RT-PCR)方法检测肺组织ICAM-1mRNA的表达。结果:与对照组相比,实验组肺静态顺应性(Cstat)、肺氧合指数(OI)、呼吸指数(RI)等肺功能指标均有显著改善(P<0.05～0.01),肺含水率明显下降(P<0.05),肺组织损伤程度明显减轻;实验组ICAM-1mRNA的表达量也较对照组显著降低(P<0.01)。结论:CPB期间经肺动脉持续灌注氧合血可减轻肺损伤、保护肺功能,而ICAM-1可能参与了这种保护机制。
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| 关 键 词： | 肺 体外循环 缺血再灌注损伤 肺动脉灌注 猪 体外循环 肺动脉 氧合血灌注 肺功能 细胞间黏附分子 表达量 影响 Cardiopulmonary Bypass During Expression Adhesion Pulmonary Function Blood Perfusion Continuous 保护机制 肺损伤 损伤程度 改善 功能指标 |
| 文章编号： | 1000-3614(2008)03-0221-04 |
| 修稿时间： | 2008年3月3日 |
The Effect of Continuous Pulmonary Perfusion With Oxygenated Blood on Pulmonary Function and Intracellular Adhesion Molecule-1 Expression During Cardiopulmonary Bypass |
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| YUAN Feng,LI Xiao-feng,ZHAO Yu-dong,et al..The Effect of Continuous Pulmonary Perfusion With Oxygenated Blood on Pulmonary Function and Intracellular Adhesion Molecule-1 Expression During Cardiopulmonary Bypass[J].Chinese Circulation Journal,2008,23(3):221-224. |
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| Authors: | YUAN Feng LI Xiao-feng ZHAO Yu-dong |
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| Institution: | YUAN Feng,LI Xiao-feng,ZHAO Yu-dong,et al.Heart Center,Beijing Children\'s Hospital Affiliated to Capital Medical University,Beijing(100045),China |
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| Abstract: | Objective:To investigate the effect of continuous pulmonary perfusion with oxygenated blood on pulmonary function and intracellular adhesion molecule-1(ICAM-1) expression during cardiopulmonary bypass(CPB).Methods:Healthy piglets were randomly divided into two groups.The control group only accepted a routine CPB,whereas the experimental group received continuous pulmonary perfusion with oxygenated blood simultaneously with CPB.Lung tissue and blood sample were obtained at various time points to measure the ... |
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| Keywords: | Lung Cardiopulmonary bypass Ischemia-reperfusion injury Swine Pig |
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